Is it okay to close MSI AfterBurner after overclocking GPU?

I've recently started overclocking my GPU using MSI Afterburner and I'm wondering if I should keep the program running in the background after applying my overclock settings.
 
The settings you change with MSI AfterBurner will remain the same even after you have closed it.

If you want different profiles (lets say one is OC'd the other is stock), then you can save custom profiles, select whichever you want, and close AfterBurner, the last settings you make will remain.

P.S This does not apply to fan curves, you gotta change fan speed manually.